Frequencies of polymorphisms in CYP2C9 and VKORC1 genes influencing warfarin metabolism in Slovak population: implication for clinical practice
نویسندگان
چکیده
منابع مشابه
Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population
OBJECTIVE Warfarin is a commonly prescribed anticoagulant for prevention of thromboembolic events. Wide inter-individual dose variation, narrow therapeutic range and risk of serious bleeding result in difficulties in achieving the therapeutic effect. The present study was designed to clarify the real biological significance of the polymorphisms of VKORC1 and cytochrome P450 2C9 (CYP2C9) in warf...
متن کاملfrequency distribution of polymorphisms of cyp2c19, cyp2c9, vkorc1 and slco1b1 genes in the yakut population
allele frequencies of single nucleotide polymorphisms (snps) are variable among different populations; therefore the study of snps in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. the main goal of the research is to study the polymorphisms of cyp2c9 , cyp2c19 , vkorc1 , and slco1b1 in yakuts. genomic dna from 229 yakut subjects we...
متن کاملAssociation of Warfarin Therapy with APOE and VKORC1 Genes Polymorphism in Iranian Population
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...
متن کاملWarfarin pharmacogenetics: polymorphisms of the CYP2C9, CYP4F2, and VKORC1 loci in a genetically admixed Omani population.
This is the first study to evaluate the spectrum and prevalence of dose-predictive genetic polymorphisms of the CYP2C9, CYP4F2 and VKORC1 loci together, in a geographically defined, ethnically admixed healthy adult Omani population sharing common lifestyle/environmental factors. Since the present-day Omani population is the result of an admixture of Caucasian, African and Asian ancestries, we c...
متن کاملEffect of Cyp2c9 and Vkorc1 Genetic Polymorphisms on Warfarin Dose Requirement in South Indian Population
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) genetic polymorphisms were strongly associated with warfarin dose requirement in Caucasians, African Americans and other populations. Our aim was to evaluate the effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirement in south Indian population. A total of 150 patients on warfarin with...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2014
ISSN: 1336-0345
DOI: 10.4149/bll_2014_109